Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for binding of thiol-containing tumour-targeting molecules like human serum albumin.

Nanogels as a Chemically Controllable Platform for Targeted Drug Delivery

Targeted nanogels: a versatile platform for drug delivery to tumors.

Although nanoparticle-based drug delivery formulations can improve the effectiveness and safety of certain anticancer drugs, many drugs, due to their chemical composition, are unsuitable for nanoparticle loading. Here, we describe a targeted nanogel drug delivery platform that can (i) encapsulate a wide range of drug chemotypes, including biological, small molecule, and cytotoxic agents; (ii) d...

A cooperative polymeric platform for tumor-targeted drug delivery.

In the pursuit of effective treatments for cancer, an emerging strategy is "active targeting", where nanoparticles are decorated with targeting ligands able to recognize and bind specific receptors overexpressed by tumor cells or tumor vasculature so that a greater fraction of the administered drugs are selectively trafficked to tumor sites. However, the implementation of this strategy has face...

Advances in Targeted Drug Delivery